Archive for December, 2018

Proper Administration of MNM to Restore NAD+ Levels

Monday, December 31st, 2018

NAD+ seems to be the closest to we have gotten to achieve the fountain of youth. As we get old, the levels of nicotinamide adenine dinucleotide levels substantially decline to approximately half of what we had in youth. Researchers have demonstrated that by boosting NAD+ levels in mice, helps in making them look and behave as they did when they were young. This is besides helping to significantly extend their lifespan.

What is NAD+

This is a crucial coenzyme that all mitochondria in our cells rely on to provide fuel for all basic functions. NAD+ also plays a critical role in establishing communication between the mitochondria and cells nucleus. According to latest research, it has been determined that there exists a direct link between declining NAD+ levels and aging in human and animal subjects.

The Decline of NAD+

When we grow older, we produce less NAD+ and the cell nucleus and mitochondrial communication is compromised. With time, this decrease will impair the ability of cells to make energy. This results in aging and disease. This is probably the main reason behind aging.

How Is NAD+ Metabolized In Humans

There are several different precursors (molecules) from which NAD+ can be synthesized. This is mainly through salvage and De Novo pathways. The salvage pathway is more predominant with NAD+ synthesis, accounting for at least 85% of the NAD+ in our bodies. Studies have further demonstrated that about 3g of NAM is metabolized to NMN then to NAD+. This can happen at least two to four times each day. NAMPT is the step that limits the rates during salvage process.

Linking NAD+ and Sublingual MNM

When we start aging, the activity of NAMPT enzymes is lowered. This eventually causes less NAM to be recycled, hence creating lower NAD+ levels. With low levels of nicotinamide adenine dinucleotide, we start experiencing disease and aging.

It will be worthwhile to note that all the supplements to boosting NAD+ can restore the levels in the liver. This, however, does not solve the deficiency of this crucial molecule throughout our bodies. In the liver, CD38 metabolizes NAD+ into NAM. Therefore, it is NAM that gets circulated to the rest of the body.

Effective Supplementation

When MNM or NAD+ are administered sublingually, the supplements are able to circumvent the two obstacles: the processing of NAM by NAMPT and the liver. Therefore, it is recommended that NAD+ or MNM (the immediate NAD+ precursor) be administered directly into the blood stream. This is more effective than ingesting large amounts of NR or NAM that get into the liver; where you will be trying to produce more MNM and NAD into your bloodstream.

In the case of mammals, all the NAD+ is used 2-4 times in a day. It gets recycled via the salvage pathway, creating at least 85% of the NAD+ in our bodies.

NAD+ and Salvage Pathway

Nicotinamide and Nicotinamide Riboside are initially changed to MNM. This is followed by conversion of MNM to NAD+. It is more correct therefore to refer to MNM as the NAD+ intermediate because it is the final stage to producing NAD+.